Abrogation of Tumor Rejection by Trypan Blue1
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چکیده
Trypan blue treatment prevented tumor-specific rejec tion in three animal model systems.These included the spontaneous rejection of tumors of mice (UVT-2051) and guinea pig (line 1 hepatoma) as well as vaccine-induced rejection of a guinea pig tumor (line 10 hepatoma). Sec ondary immune reactions to line 10 cell challenges were not abolished by trypan blue treatment. Although trypan blue is a potent inhibitor of macrophage cytotoxicity in vitro, the mechanism by which it inhibited tumor-specific rejection has not been established.
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تاریخ انتشار 2006